The USS Rathburne (FF-1057) was a Knox class frigate of the US Navy. Despite the different spelling, she was named for Continental Navy officer John Rathbun (1746-1782), and was laid down 8 January 1968 by Lockheed Shipbuilding and Construction Company at Seattle, Washington. She was launched on 2 May 1969, sponsored by Mrs. Charles A. Bowsher, and commissioned on 16 May 1970 with Commander Richard B. Evans in command.
Rathburne appeared in a 1972 episode of the television series Hawaii Five-O.
Rathburne was decommissioned on 14 February 1992 and stricken from the Naval Vessel Register on 11 January 1995. She was sunk as a target during fleet training exercise RIMPAC 2002 on 5 July 2002.